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Based on the ATLAS study in heart failure patients, high doses (325 to 35 mg/day) did not significantly change overall mortality rate compared to low doses (25 to 5 mg/day PO); however, the high dose group had a lower hospitalization rate for heart failure!

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Resistance genes to tetracyclines often occur on plasmids or other transferable elements such as transposons [ 5]? Another possible adverse effect specific for ACE inhibitors, trileptal cost but not for other RAAS blockers, is an increase in bradykinin level?
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